Since 2014, the Ukrainian state has been suffering from the economic, political and social crisis, which has deepened due to constant warfare conducted by the pro-Russian terrorist groups in the Eastern Ukraine and the Kremlin annexation of the Crimean peninsula. These factors permanently influence the internal political stability of the state and personal security of its population. The latter cannot be fully guaranteed by official authorities, as a significant number of people are subjected to pressure of purely humanitarian nature. Today, the humanitarian crisis is amplified by the fact that many people from the East of Ukraine still reside in the military operations area or struggle for their lives having acquired the status of internally displaced persons. This situation leads both to a significant imbalance in implementation of the internal policy and brings humanitarian issues to the foreign policy domain. Thus, this article aims to explore a grade of impact and a role of the humanitarian factor in the implementation of domestic policy of Ukraine, as well as in the realization of its diplomatic activities in the world political arena.