European integration faces internal resistance at least for the past decade. Accompanied by a tremendous external pressure – from illegal flow of migrants to direct and indirect destructive “arrows” from the side of Russia (especially after 2013), the European political space found itself directly threatened by fragmentation. Analysing the case of the Black Sea region vis-a-vis the EU, the author argues that any disintegration in Europe at the regional level is threatening its security. Thus, the EU and its neighbours, in line with Europeanisation, have to preserve and continue to use all the mechanisms of inter-regional cooperation to keep them as protective security measures, not letting anyone to turn post-bipolar regionalisation into an instrument of division and conflict.