The primary purpose of the article is to correlate a predominant position of some regions with the intensity of separatist movements there. Two tendencies of peripheral separatism have been discovered in Europe. The role of the European continent is confirmed in representing different independent regional and interregional organisations, i.e. through the Assembly of European Regions comprising roughly 300 regional entities. A brief analysis has been made of several regions facing the most evident separatist tendencies and ethnic turbulence. Coincidence factor and prosperity syndrome as accelerant of separatist tendencies have been noted in the Western and Eastern parts of Europe, pointing out different surroundings and the same triggering motivation. And finally, some of most effective instruments to withstand separatist pressure, backed by external powers in proxy-war environments, have been suggested.